Pair Name	Morin Hydrate, Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	ATG5	hsa9474
	Down-regulation	Expression	ATG7	hsa10533
	Down-regulation	Expression	ATM	hsa472
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BECN1	hsa8678
	Up-regulation	Expression	BID	hsa637
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	HMGB1	hsa3146
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Down-regulation	Expression	PARP1	hsa142
	Up-regulation	Expression	SQSTM1	hsa8878
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vivo Model	HepG2 cells were cultured, harvested and re-suspended in sterile PBS. A total of five million cells (5 × 106) were injected into the right flank of the animals subcutaneously.
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Morin Hydrate, Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	HMGB1	hsa3146
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Down-regulation	Expression	PARP1	hsa142
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vivo Model	A total of 5×10⁶ cells were subcutaneously injected into the right flank of the mice.
Result	The combination of Morin hydrate with cisplatin may be a promising therapeutic strategy to enhance the efficacy of conventional chemotherapeutic drugs.